Wentworth
Institute of Technology
Structural And Functional Organization Of The Synapse
Synapses play a central role in the brain by mediating signal transmission between neurons. This book provides a fundamental description of the synapse by leading experts in the field. Each individual synapse carries out its numerous functions in a tiny space, thereby requiring an exquisite molecula...
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Boston, MA :
Springer US,
2008.
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| Subjects: | |
| Online Access: |
Full text (Wentworth users only). |
MARC
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| 505 | 0 | |a Introduction -- Transport and Storage of neurotransmitters -- The neurotransmitter release machinery -- Endocytic retrieval of synaptic vesicles -- Linking the release machinery to neuronal excitation: SNARE binding to presynaptic Ca channels -- Attaching the release machinery with the synaptic cleft matrix: Ca channel interaction with laminin -- Connect the presynaptic and postsynaptic site: neurexins, neuroligins, SynCAMs, and their intracellular binding partners -- Structural and functional aspects of glutamate binding to the AMPA receptor -- The role of Stargazin and PSD95 in AMPA receptor accumulation at the postsynaptic site -- Cell biology and biochemistry of the NMDA R -- Physiology and Biophysics of Glutamate receptors -- The regulators: postsynaptic targeting of protein kinases and phosphatases -- The postsynaptic scaffolding proteins -- The postsynaptic cytoskeleton -- Synpatic plasticity: LTP and LTD -- Development of the Synapse -- Metabotropic Glutamate receptors -- The GABAergic synapse -- The glycinergic synapse -- Postsynaptic ion channels (SK K channels, which regulate NMDA receptor activity, Ca channels -- Stroke: Excitotoxicity by glutamate -- Synaptic contributions to epilepsy -- Huntington’s and related polyglutamine expansion diseases and their effect on the synapse -- Dysregulation of synaptic function in Alzheimer’s disease -- The role of synaptic alterations in chronic pain -- Autism from a synaptic perspective -- Anxiety disorders -- Depression -- Schizophrenia. | |
| 520 | |a Synapses play a central role in the brain by mediating signal transmission between neurons. This book provides a fundamental description of the synapse by leading experts in the field. Each individual synapse carries out its numerous functions in a tiny space, thereby requiring an exquisite molecular and functional arrangement. This book describes the molecular structure and cellular function of central synapses in the brain, providing a detailed view of the brain’s fundamental unit of information storage. | ||
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