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|2 23/eng/20240626
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| 245 |
0 |
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|a Telomeres :
|b chromosome sentinels /
|c coordinated by Carole Saintom?e.
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| 264 |
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1 |
|a London, UK :
|b ISTE Ltd ;
|a Hoboken, NJ :
|b John Wiley & Sons, Inc,
|c 2023.
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| 264 |
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4 |
|c ?2023
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| 300 |
|
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|a 1 online resource (399 p.).
|
| 336 |
|
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
0 |
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|a Sciences. Biology. Molecular, structural and biochemical biology
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| 500 |
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|a 5.6. Telomeres, replicative senescence, aging and genomic instability
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| 505 |
0 |
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|a Cover -- Title Page -- Copyright Page -- Contents -- Foreword -- Chapter 1. Telomeres: All's Well That Ends Well -- 1.1. Introduction -- 1.2. The beginning of the end -- 1.2.1. Chemists and biophysicists at work: G-quartets and G-quadruplexes disclose themselves -- 1.2.2. Biologists at work: telomeres disclose themselves -- 1.2.3. When and where G-quadruplexes and telomeres met -- 1.3. Telomeric architectures: from ciliates to other eukaryotes -- 1.3.1. Telomeric DNA and telomeric proteins -- 1.3.2. Telomeric structures -- 1.4. G-quadruplexes at telomeres
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| 505 |
8 |
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|a 1.4.1. Secondary structures formed by repeats of telomeric motifs -- 1.4.2. G4s at telomeres: friendly or unfriendly structures? -- 1.5. References -- Chapter 2. Methods to Measure Telomere Lengths -- 2.1. Why does telomere length matter? -- 2.2. Methods for measuring telomere length -- 2.2.1. Terminal restriction fragment analysis (TRF) -- 2.2.2. Single telomere length analysis -- 2.2.3. Telomere shortest length assay -- 2.2.4. Quantitative-polymerase chain reaction -- 2.2.5. Quantitative-fluorescence in situ hybridization -- 2.2.6. Flow-fluorescence in situ hybridization -- 2.3. References
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| 505 |
8 |
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|a Chapter 3. The Shelterin Complex -- 3.1. TRF1 and TRF2, structurally alike but... -- 3.1.1. Domains organization -- 3.1.2. Biological roles -- 3.2. RAP1 -- 3.3. TIN2 -- 3.4. TPP1-POT1 -- 3.5. Quaternary structure of the shelterin -- 3.6. Concluding remarks -- 3.7. References -- Chapter 4. Mammalian Telomere Organization and Dynamics in the Nuclear Volume -- 4.1. Introduction -- 4.2. Nuclear envelope and lamins: orchestrators of cell and genome architecture -- 4.2.1. The nuclear envelope landmarks -- 4.2.2. The nuclear envelope as a scaffold to organize nuclear architecture
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| 505 |
8 |
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|a 4.2.3. Nuclear envelope disassembly during mitosis -- 4.3. Interplay between telomeres and nuclear structures -- 4.4. Telomere tethering to the NE to promote meiotic pairing -- 4.5. Telomere organization and dynamics in the nucleus -- 4.6. Interaction between telomere chromatin and lamins during post-mitotic nuclear assembly -- 4.7. Interaction between telomere chromatin and lamins for telomere maintenance -- 4.8. Conclusion -- 4.9. References -- Chapter 5. Saccharomyces cerevisiae, a Model at the Forefront of Telomere Biology -- 5.1. Introduction
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| 505 |
8 |
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|a 5.2. Telomere characterization: various experimental organisms for first historical experiments -- 5.3. Protection and proliferation: the telomere dilemma -- 5.3.1. Telomeric sequences: pattern conservation and length variations -- 5.3.2. Telomeric proteins -- 5.3.3. TERRA or telomere transcription -- 5.4. Telomere maintenance -- 5.4.1. The difficulties of moving replication fork through telomeres -- 5.4.2. The end replication problem -- 5.4.3. Telomerase: a solution to the problem of telomere shortening -- 5.5. Telomeres: one size for one identity
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| 588 |
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|a Description based on online resource; title from digital title page (viewed on June 26, 2024).
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| 650 |
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0 |
|a Telomere.
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| 700 |
1 |
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|a Saintom?e, Carole,
|e editor.
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|i Print version:
|a Saintome, Carole
|t Telomeres
|d Newark : John Wiley & Sons, Incorporated,c2024
|z 9781789450972
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Wentworth
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